Linked Life Data

2060704

Source:http://linkedlifedata.com/resource/pubmed/id/2060704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-8
pubmed:abstractText
Previous studies, using actinomycin D, suggested that the rate of mRNA degradation in chicken embryo lens epithelial cells decreased sharply between Days 11 and 13 of development (Yoshida and Katoh, Exp. Eye Res. 11, 1971; Exp. Cell Res. 71, 1972). We repeated these studies and directly measured the effects of actinomycin on lens mRNAs. Although actinomycin decreased [3H]uridine incorporation greater than 90%, only modest decreases in methionine incorporation were detected. Treatment for 6 hr had no detectable effect on delta-crystallin mRNA levels or on the relative amounts of proteins synthesized in an in vitro translation system. Unlike the previous studies, we did not find significant changes in the stability of lens epithelial mRNAs during development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-41
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Messenger RNA stabilization in chicken lens development: a reexamination.
pubmed:affiliation
Department of Anatomy, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814-4799.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.