Source:http://linkedlifedata.com/resource/pubmed/id/20605922
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 15
|
| pubmed:dateCreated |
2010-10-13
|
| pubmed:abstractText |
In muscle cells, a complex network of Z-disc proteins allows proper reception, transduction and transmission of mechanical and biochemical signals. Mutations in genes encoding different Z-disc proteins such as integrin-linked kinase (ILK) and nexilin have recently been shown to cause heart failure by distinct mechanisms such as disturbed mechanosensing, altered mechanotransduction or mechanical Z-disc destabilization. We identified core-binding factor ? (CBF?) as an essential component for maintaining sarcomeric Z-disc and myofilament organization in heart and skeletal muscle. In CBF?-deficient cardiomyocytes and skeletal-muscle cells, myofilaments are thinned and Z-discs are misaligned, leading to progressive impairment of heart and skeletal-muscle function. Transcription of the gene encoding CBF? mainly depends on JunB activity. In JunB-morphant zebrafish, which show a heart-failure phenotype similar to that of CBF?-deficient zebrafish, transcript and protein levels of CBF? are severely reduced. Accordingly, ectopic expression of CBF? can reconstitute cardiomyocyte function and rescue heart failure in JunB morphants, demonstrating for the first time an essential role of JunB-CBF? signaling for maintaining sarcomere architecture and function.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1477-9137
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
123
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2613-20
|
| pubmed:meshHeading |
pubmed-meshheading:20605922-Amino Acid Sequence,
pubmed-meshheading:20605922-Animals,
pubmed-meshheading:20605922-Core Binding Factor beta Subunit,
pubmed-meshheading:20605922-Heart Failure,
pubmed-meshheading:20605922-Humans,
pubmed-meshheading:20605922-Immunoblotting,
pubmed-meshheading:20605922-In Situ Hybridization,
pubmed-meshheading:20605922-Mice,
pubmed-meshheading:20605922-Microscopy, Electron, Transmission,
pubmed-meshheading:20605922-Molecular Sequence Data,
pubmed-meshheading:20605922-Muscle, Skeletal,
pubmed-meshheading:20605922-Myocardium,
pubmed-meshheading:20605922-Myocytes, Cardiac,
pubmed-meshheading:20605922-Polymerase Chain Reaction,
pubmed-meshheading:20605922-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:20605922-Sarcomeres,
pubmed-meshheading:20605922-Sequence Homology, Amino Acid,
pubmed-meshheading:20605922-Zebrafish
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.
|
| pubmed:affiliation |
Department of Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|