Source:http://linkedlifedata.com/resource/pubmed/id/20605462
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2010-7-30
|
| pubmed:abstractText |
Mortality and serious long-term sequelae still occur in about 50% of patients with tuberculous meningitis. The frequency and the clinical features of neurological and systemic complications were determined in a retrospective review of 104 patients with tuberculous meningitis. Complications occurred in 81 patients (78%). The most common complications were: hyponatraemia 49%, hydrocephalus 42%, stroke 33%, cranial nerve palsies 29%, epileptic seizures 28%, diabetes insipidus 6%, tuberculoma 3%, myeloradiculopathy 3% and hypothalamic syndrome 3%. The most common iatrogenic complication was hepatotoxicity related to anti-tuberculosis treatment in seven patients. Twenty-three patients (22%) died. At last follow-up one patient (1%) remained in a persistent vegetative state, 14 patients (13%) had severe disability and 12 patients (12%) were moderately disabled. The most common complications in the 81 long-term survivors were cognitive impairment (12%) and epilepsy (11%). Neurological and systemic complications of tuberculous meningitis were common and were important causes of mortality and long-term morbidity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1532-2653
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
17
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1114-8
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| pubmed:meshHeading |
pubmed-meshheading:20605462-Adolescent,
pubmed-meshheading:20605462-Adult,
pubmed-meshheading:20605462-Aged,
pubmed-meshheading:20605462-Aged, 80 and over,
pubmed-meshheading:20605462-Antitubercular Agents,
pubmed-meshheading:20605462-Child,
pubmed-meshheading:20605462-Child, Preschool,
pubmed-meshheading:20605462-Female,
pubmed-meshheading:20605462-Follow-Up Studies,
pubmed-meshheading:20605462-Hospitals, Urban,
pubmed-meshheading:20605462-Humans,
pubmed-meshheading:20605462-Hydrocephalus,
pubmed-meshheading:20605462-Hyponatremia,
pubmed-meshheading:20605462-Infant,
pubmed-meshheading:20605462-Male,
pubmed-meshheading:20605462-Middle Aged,
pubmed-meshheading:20605462-Nervous System Diseases,
pubmed-meshheading:20605462-New Zealand,
pubmed-meshheading:20605462-Retrospective Studies,
pubmed-meshheading:20605462-Stroke,
pubmed-meshheading:20605462-Tuberculosis, Meningeal,
pubmed-meshheading:20605462-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Neurological and systemic complications of tuberculous meningitis and its treatment at Auckland City Hospital, New Zealand.
|
| pubmed:affiliation |
Department of Neurology, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand. neila@adhb.govt.nz
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|