Linked Life Data

2060500

Source:http://linkedlifedata.com/resource/pubmed/id/2060500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-2
pubmed:abstractText
In rats, electrographic seizure activity was recorded from both the inferior collicular cortex and the deep prepiriform after i.p. administration of 15 mumol/kg bicuculline, a dose which produced a variety of seizure behaviors. electrographic spikes recorded from the deep prepiriform cortex coincided with myoclonic jerks, while both brain areas exhibited an increase in afterdischarge frequency at the onset of forelimb tonic extension. Conversely, afterdischarge activity was recorded in both brain regions, while no seizure behaviors were apparent, providing examples of dissociation between electrographic and behavioral seizure activity. However, when functional interactions were assessed, the tonic-clonic behaviors produced by kindling stimulation of the inferior collicular cortex were prevented by microinjections of procaine into the deep prepiriform cortex. Thus, a forebrain site, that has been associated with limbic seizure activity, also can modulate seizure generalization from the inferior collicular cortex into the forebrain.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0920-1211
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Seizure interactions between the inferior collicular cortex and the deep prepiriform cortex.
pubmed:affiliation
Department of Psychiatry, University of North Carolina, Chapel Hill 27599-7520.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't