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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-9-24
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pubmed:abstractText |
Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1478-6362
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R130
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20604941-Adipokines,
pubmed-meshheading:20604941-Animals,
pubmed-meshheading:20604941-Behavior, Animal,
pubmed-meshheading:20604941-Cartilage,
pubmed-meshheading:20604941-Dietary Fats,
pubmed-meshheading:20604941-Disease Progression,
pubmed-meshheading:20604941-Extracellular Matrix,
pubmed-meshheading:20604941-Female,
pubmed-meshheading:20604941-Interleukin-1,
pubmed-meshheading:20604941-Mice,
pubmed-meshheading:20604941-Mice, Inbred C57BL,
pubmed-meshheading:20604941-Motor Activity,
pubmed-meshheading:20604941-Obesity,
pubmed-meshheading:20604941-Osteoarthritis, Knee,
pubmed-meshheading:20604941-Pain,
pubmed-meshheading:20604941-Risk Factors,
pubmed-meshheading:20604941-Severity of Illness Index,
pubmed-meshheading:20604941-Swine,
pubmed-meshheading:20604941-Temporomandibular Joint Disorders,
pubmed-meshheading:20604941-Tissue Culture Techniques
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pubmed:year |
2010
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pubmed:articleTitle |
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. Tim-Griffin@omrf.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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