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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
Tissue fibrosis and vascular disease are hallmarks of systemic sclerosis (SSc). Transforming growth factor beta (TGFbeta) is a key-player in fibroblast activation and tissue fibrosis in SSc. In contrast to fibrosis, evidence for a role of TGFbeta in vascular disease of SSc is scarce. Using a transgenic mouse model with fibroblast-specific expression of a kinase-deficient TGFbeta receptor type II, Derrett-Smith and colleagues demonstrate that aberrant TGFbeta signaling in fibroblasts might result in activation of vascular smooth muscle cells and architectural changes of the vessel wall of the aorta.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1478-6362
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125
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pubmed:dateRevised |
2010-12-21
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pubmed:meshHeading |
pubmed-meshheading:20602813-Animals,
pubmed-meshheading:20602813-Aorta,
pubmed-meshheading:20602813-Disease Models, Animal,
pubmed-meshheading:20602813-Fibroblasts,
pubmed-meshheading:20602813-Mice,
pubmed-meshheading:20602813-Mice, Transgenic,
pubmed-meshheading:20602813-Muscle, Smooth, Vascular,
pubmed-meshheading:20602813-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20602813-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:20602813-Scleroderma, Systemic,
pubmed-meshheading:20602813-Signal Transduction,
pubmed-meshheading:20602813-Transforming Growth Factor beta,
pubmed-meshheading:20602813-Vascular Diseases
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pubmed:year |
2010
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pubmed:articleTitle |
Vascular alterations upon activation of TGFbeta signaling in fibroblasts--implications for systemic sclerosis.
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pubmed:publicationType |
Editorial,
Comment
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