Linked Life Data

20601221

Source:http://linkedlifedata.com/resource/pubmed/id/20601221

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-7
pubmed:abstractText
Positional displacement of helix12 (H12) in the estrogen receptor alpha, which belongs to the nuclear receptor (NR) superfamily, is studied by the molecular dynamics (MD) simulation and the linear response theory. Tendency of the H12 to swing up upon ligand binding, which is consistent with X-ray structures and earlier MD simulations, is reproduced by the calculation of the conformational fluctuation in apo state and the response to the external perturbation. Our study thus provides an interpretation of the positional change of the H12 such that it is derived by the preexistent swing-up motion where the ligand binding works only as a trigger. Our finding, which illustrates underlying mechanism of the H12 motion, would contribute to finding a way to regulate the transcriptional activity by synthesized ligands because the transcriptional activity of the NR is governed by the position of the H12.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-3002
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Print
pubmed:volume
1804
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1832-40
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
An interpretation of positional displacement of the helix12 in nuclear receptors: preexistent swing-up motion triggered by ligand binding.
pubmed:affiliation
Graduate School of Human Development and Environment, Kobe University, 3-11, Tsurukabuto, Nada, Kobe 657-8501, Japan. chiduru@tokai-u.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't