Linked Life Data

20600821

Source:http://linkedlifedata.com/resource/pubmed/id/20600821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-13
pubmed:abstractText
This paper reviews studies in vivo and in vitro on the reproductive and developmental toxicity of manufactured nanomaterials including metallic and metal oxide-based particles, fullerenes (C(60)), carbon black (CB), and luminescent particles. Studies in vivo showed increased allergic susceptibility in offspring of mouse dams intranasally insufflated with respirable-size titanium dioxide (TiO(2)), adverse effects on spermatogenesis and histopathological changes in the testes and changes in gene expression in the brain of mouse offspring after maternal subcutaneous injection of TiO(2) nanoparticles, transfer to rat fetuses of radiolabeled gold nanoparticles and C(60) after maternal intravenous injection, death and morphological abnormalities in mouse embryos after maternal intraperitoneal injection of C(60), and adverse effects on spermatogenesis in mouse offspring after maternal intratracheal instillation of CB nanoparticles. Studies in vitro revealed that TiO(2) and CB nanoparticles affected the viability of mouse Leydig cells, that gold nanoparticles reduced the motility of human sperm, that silver, aluminum, and molybdenum trioxide were toxic to mouse spermatogonia stem cells, that silica nanoparticles and C(60) inhibited the differentiation of mouse embryonic stem cells and midbrain cells, respectively, and that cadmium selenium-core quantum dots inhibited pre- and postimplantation development of mouse embryos. Although this paper provides initial information on the potential reproductive and developmental toxicity of manufactured nanomaterials, further studies, especially in vivo, using characterized nanoparticles, relevant routes of administration, and doses closely reflecting expected levels of exposure are needed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1873-1708
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-52
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Reproductive and developmental toxicity studies of manufactured nanomaterials.
pubmed:affiliation
Research Institute of Science for Safety and Sustainability, National Institute of Advanced Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan. ema-makoto@aist.go.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't