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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-17
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pubmed:abstractText |
In a previous study, we found increased plasma soluble receptor for interleukin-6 (sIL-6R) levels in patients with essential thrombocythemia (ET) that could promote megakaryopoiesis through IL-6 binding and further interaction with the signal transducer gp130. Here we have searched for the cell source of sIL-6R within mononuclear cells in these patients and the underlying abnormalities involved in its overproduction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-2399
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
868-876.e1
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pubmed:meshHeading |
pubmed-meshheading:20600579-Adolescent,
pubmed-meshheading:20600579-Adult,
pubmed-meshheading:20600579-Aged,
pubmed-meshheading:20600579-Cell Membrane,
pubmed-meshheading:20600579-Cells, Cultured,
pubmed-meshheading:20600579-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20600579-Female,
pubmed-meshheading:20600579-Flow Cytometry,
pubmed-meshheading:20600579-Gene Expression Regulation,
pubmed-meshheading:20600579-Humans,
pubmed-meshheading:20600579-Janus Kinase 2,
pubmed-meshheading:20600579-Lymphocytes,
pubmed-meshheading:20600579-Male,
pubmed-meshheading:20600579-Middle Aged,
pubmed-meshheading:20600579-Monocytes,
pubmed-meshheading:20600579-Mutation,
pubmed-meshheading:20600579-Receptors, Interleukin-6,
pubmed-meshheading:20600579-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20600579-Solubility,
pubmed-meshheading:20600579-Thrombocythemia, Essential,
pubmed-meshheading:20600579-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Abnormal regulation of soluble and anchored IL-6 receptor in monocytes from patients with essential thrombocythemia.
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pubmed:affiliation |
Sección Hematología Investigación, UE IDIM-CONICET, Instituto Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. npgoette@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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