|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001565,
umls-concept:C0003241,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0020971,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0039195,
umls-concept:C0042210,
umls-concept:C0205263,
umls-concept:C0700038,
umls-concept:C1711351
|
|
pubmed:issue |
34
|
|
pubmed:dateCreated |
2010-7-26
|
|
pubmed:abstractText |
A vaccine against heterosexual transmission by human immunodeficiency virus (HIV) should generate cytotoxic and antibody responses in the female genital tract and in extra-genital organs. We report that sublingual immunization with HIV-1 gp41 and a reverse transcriptase polypeptide coupled to the cholera toxin B subunit (CTB) induced gp41-specific IgA antibodies and antibody-secreting cells, as well as reverse transcriptase-specific CD8 T cells in the genital mucosa, contrary to intradermal immunization. Conjugation of the reverse transcriptase peptide to CTB favored its cross-presentation by human dendritic cells to a T cell line from an HIV(+) patient. Sublingual vaccination could represent a promising vaccine strategy against heterosexual transmission of HIV-1.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1873-2518
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
2
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5582-90
|
|
pubmed:meshHeading |
pubmed-meshheading:20600505-AIDS Vaccines,
pubmed-meshheading:20600505-Administration, Sublingual,
pubmed-meshheading:20600505-Animals,
pubmed-meshheading:20600505-Cross-Priming,
pubmed-meshheading:20600505-Dendritic Cells,
pubmed-meshheading:20600505-Female,
pubmed-meshheading:20600505-Genitalia, Female,
pubmed-meshheading:20600505-HIV Antibodies,
pubmed-meshheading:20600505-HIV Envelope Protein gp41,
pubmed-meshheading:20600505-HIV Infections,
pubmed-meshheading:20600505-Humans,
pubmed-meshheading:20600505-Immunoglobulin A,
pubmed-meshheading:20600505-Immunoglobulin G,
pubmed-meshheading:20600505-Mice,
pubmed-meshheading:20600505-Mice, Inbred BALB C,
pubmed-meshheading:20600505-Mice, Inbred C57BL,
pubmed-meshheading:20600505-Mice, Transgenic,
pubmed-meshheading:20600505-Mucous Membrane,
pubmed-meshheading:20600505-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Sublingual immunization with an HIV subunit vaccine induces antibodies and cytotoxic T cells in the mouse female genital tract.
|
|
pubmed:affiliation |
Inserm, U634, Faculté de Médecine Pasteur, 06107 Nice cedex 2, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
