| pubmed-article:20600463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0003467 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C1510586 | lld:lifeskim |
| pubmed-article:20600463 | lifeskim:mentions | umls-concept:C1333254 | lld:lifeskim |
| pubmed-article:20600463 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20600463 | pubmed:dateCreated | 2010-9-13 | lld:pubmed |
| pubmed-article:20600463 | pubmed:abstractText | The primary objective of the present study was to examine whether a combination of parent-child DRD4 genotypes results in more informative biomarkers of oppositional, separation anxiety, and repetitive behaviors in children with autism spectrum disorder (ASD). Based on prior research indicating the 7-repeat allele as a potential risk variant, participants were sorted into one of four combinations of parent-child genotypes. Owing to the possibility of parent-of-origin effects, analyses were conducted separately for mother-child (MC) and father-child (FC) dyads. Mothers completed a validated DSM-IV-referenced rating scale. Partial eta-squared (?p(2)) was used to determine the magnitude of group differences: 0.01-0.06=small, 0.06-0.14=moderate, and >0.14=large. Analyses indicated that children in MC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe mother-rated oppositional-defiant (?p(2)=0.11) and separation anxiety (?p(2)=0.19) symptoms. Conversely, youths in FC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe obsessive-compulsive behaviors (?p(2)=0.19) and tics (?p(2)=0.18). Youths whose parents were both noncarriers had less severe tics than peers with at least one parental carrier, and the effect size was large (?p(2)=0.16). There was little evidence that noncarrier children were rated more severely by mothers who were carriers versus noncarriers. Transmission Disequilibrium Test analyses provided preliminary evidence for undertransmission of the 2-repeat allele in youths with more severe tics (p=0.02). Parent genotype may be helpful in constructing prognostic biomarkers for behavioral disturbances in ASD; however, findings are tentative pending replication with larger, independent samples. | lld:pubmed |
| pubmed-article:20600463 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20600463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20600463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20600463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20600463 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20600463 | pubmed:issn | 1878-4216 | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:GadowKenneth... | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:FinchStephen... | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:MendellNancy... | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:XuWenjieW | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:DeVincentCarl... | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:OlvetDoreen... | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:HatchwellEliE | lld:pubmed |
| pubmed-article:20600463 | pubmed:author | pubmed-author:PisarevskayaV... | lld:pubmed |
| pubmed-article:20600463 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20600463 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20600463 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20600463 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20600463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20600463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20600463 | pubmed:pagination | 1208-14 | lld:pubmed |
| pubmed-article:20600463 | pubmed:dateRevised | 2011-10-3 | lld:pubmed |
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| pubmed-article:20600463 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20600463 | pubmed:articleTitle | Parent-child DRD4 genotype as a potential biomarker for oppositional, anxiety, and repetitive behaviors in children with autism spectrum disorder. | lld:pubmed |
| pubmed-article:20600463 | pubmed:affiliation | Department of Psychiatry, Division of Child and Adolescent Psychiatry, Cody Center for Autism and Developmental Disabilities (Pediatrics), Putnam Hall, South Campus, Stony Brook University, Stony Brook, NY 11794-8790, USA. kenneth.gadow@stonybrook.edu | lld:pubmed |
| pubmed-article:20600463 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20600463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20600463 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:1815 | entrezgene:pubmed | pubmed-article:20600463 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20600463 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20600463 | lld:entrezgene |
