Source:http://linkedlifedata.com/resource/pubmed/id/20600463
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2010-9-13
|
| pubmed:abstractText |
The primary objective of the present study was to examine whether a combination of parent-child DRD4 genotypes results in more informative biomarkers of oppositional, separation anxiety, and repetitive behaviors in children with autism spectrum disorder (ASD). Based on prior research indicating the 7-repeat allele as a potential risk variant, participants were sorted into one of four combinations of parent-child genotypes. Owing to the possibility of parent-of-origin effects, analyses were conducted separately for mother-child (MC) and father-child (FC) dyads. Mothers completed a validated DSM-IV-referenced rating scale. Partial eta-squared (?p(2)) was used to determine the magnitude of group differences: 0.01-0.06=small, 0.06-0.14=moderate, and >0.14=large. Analyses indicated that children in MC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe mother-rated oppositional-defiant (?p(2)=0.11) and separation anxiety (?p(2)=0.19) symptoms. Conversely, youths in FC dyads with matched genotypes had the least (7-/7-) and most (7+/7+) severe obsessive-compulsive behaviors (?p(2)=0.19) and tics (?p(2)=0.18). Youths whose parents were both noncarriers had less severe tics than peers with at least one parental carrier, and the effect size was large (?p(2)=0.16). There was little evidence that noncarrier children were rated more severely by mothers who were carriers versus noncarriers. Transmission Disequilibrium Test analyses provided preliminary evidence for undertransmission of the 2-repeat allele in youths with more severe tics (p=0.02). Parent genotype may be helpful in constructing prognostic biomarkers for behavioral disturbances in ASD; however, findings are tentative pending replication with larger, independent samples.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1878-4216
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1208-14
|
| pubmed:dateRevised |
2011-10-3
|
| pubmed:meshHeading |
pubmed-meshheading:20600463-Adolescent,
pubmed-meshheading:20600463-Analysis of Variance,
pubmed-meshheading:20600463-Anxiety Disorders,
pubmed-meshheading:20600463-Attention Deficit and Disruptive Behavior Disorders,
pubmed-meshheading:20600463-Biological Markers,
pubmed-meshheading:20600463-Child,
pubmed-meshheading:20600463-Child, Preschool,
pubmed-meshheading:20600463-Child Development Disorders, Pervasive,
pubmed-meshheading:20600463-Family Health,
pubmed-meshheading:20600463-Female,
pubmed-meshheading:20600463-Gene Frequency,
pubmed-meshheading:20600463-Genotype,
pubmed-meshheading:20600463-Humans,
pubmed-meshheading:20600463-Linkage Disequilibrium,
pubmed-meshheading:20600463-Male,
pubmed-meshheading:20600463-Obsessive-Compulsive Disorder,
pubmed-meshheading:20600463-Parent-Child Relations,
pubmed-meshheading:20600463-Parents,
pubmed-meshheading:20600463-Psychiatric Status Rating Scales,
pubmed-meshheading:20600463-Receptors, Dopamine D4,
pubmed-meshheading:20600463-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:20600463-Tic Disorders
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Parent-child DRD4 genotype as a potential biomarker for oppositional, anxiety, and repetitive behaviors in children with autism spectrum disorder.
|
| pubmed:affiliation |
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Cody Center for Autism and Developmental Disabilities (Pediatrics), Putnam Hall, South Campus, Stony Brook University, Stony Brook, NY 11794-8790, USA. kenneth.gadow@stonybrook.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|