Linked Life Data

20600446

Source:http://linkedlifedata.com/resource/pubmed/id/20600446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-17
pubmed:abstractText
A major subset of human peripheral blood ?? T cells expresses the V?2V?2 T cell receptor and responds to malignant or infectious diseases. We noted significant differences in the numbers of V?2V?2 T cells in blood samples from healthy Caucasian CA or African American (AA) donors. On average, CA donors had 3.71% ± 4.37% V?2 cells (as a percentage of total lymphocytes) compared with 1.18% ± 2.14% V?2 cells for AA donors (p < 0.0001). Age and race had the greatest impact on V?2 cell levels; the effect of age was similar for both racial groups. The V?2 cell population was dominated, for both donor groups, by cells expressing the V?2-J?1.2 V?2 T cell receptor, an apparent result of strong positive selection and there was substantial overlap in the public V?2 clonotypes from both racial groups. Mechanisms for selection and amplification of V?2 cells are nearly identical for both groups, despite the significant difference in baseline levels. These data show that appropriate controls, matched for age and race, may be required for clinical studies of V?2V?2 T cells in infectious disease or cancer and raise important questions about the mechanisms regulating the levels of circulating V?2 cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1879-1166
pubmed:author
pubmed:copyrightInfo
2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
968-75
pubmed:dateRevised
2011-10-3
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Impact of age, gender, and race on circulating ?? T cells.
pubmed:affiliation
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural