Linked Life Data

20600203

Source:http://linkedlifedata.com/resource/pubmed/id/20600203

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-8-23
pubmed:abstractText
A novel and practical procedure was developed for the preparation of steroidal[17,16-d]pyrimidines by chlorotrimethylsilane (TMSCl)-promoted one-pot multicomponent Biginelli-like condensations of steroid-17-ones, urea and aromatic aldehydes. First, treatment of the steroid-17-ones with urea and aromatic aldehydes in dimethylformamide (DMF)/acetonitrile (ACN) gives the corresponding Biginelli products, following the aromatising reaction of the Biginelli products at the same time under air to yield the desired steroidal[17,16-d]pyrimidines (78-88%). Since steroidal[17,16-d]pyrimidines with hydroxyl group can be subsequently converted into steroidal[17,16-d]pyrimidine derivatives, this general method provides a highly efficient route to these biologically important compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1878-5867
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1033-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Chlorotrimethylsilane-promoted one-pot synthesis of steroidal[17,16-d]pyrimidines.
pubmed:affiliation
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, PR China. wangcd@yzu.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't