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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-10-4
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pubmed:abstractText |
Deleted in liver cancer 1 (DLC1), which encodes a Rho GTPase activating protein, is a bona fide tumor suppressor in hepatocellular carcinoma. Underexpression of DLC1 in cancer has been attributed to genomic deletion and epigenetic silencing. However, the regulatory mechanism of the tumor suppressive activity of DLC1 remains elusive. In this study, we elucidated a novel post-translational modification by which the activity of DLC1 is functionally regulated.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1397-407
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20600027-Animals,
pubmed-meshheading:20600027-Cell Line,
pubmed-meshheading:20600027-Cell Transformation, Neoplastic,
pubmed-meshheading:20600027-GTPase-Activating Proteins,
pubmed-meshheading:20600027-Humans,
pubmed-meshheading:20600027-Liver Neoplasms,
pubmed-meshheading:20600027-Male,
pubmed-meshheading:20600027-Mice,
pubmed-meshheading:20600027-Mice, Inbred BALB C,
pubmed-meshheading:20600027-Neoplasm Metastasis,
pubmed-meshheading:20600027-Phosphorylation,
pubmed-meshheading:20600027-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20600027-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
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pubmed:affiliation |
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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