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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-9-13
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pubmed:abstractText |
IL-12R?2(-/-) mice, which are unresponsive to IL-12, develop severe experimental autoimmune encephalomyelitis (EAE). The mechanisms for enhanced autoimmunity are incompletely understood. We report that in IL-12R?2(-/-) mice, thymocytes undergo markedly accelerated maturation. This occurs at the transition from a double positive (DP) to a single positive (SP) phenotype, resulting in higher numbers of CD4 and CD8 SP cells, and to a lesser extent at the transition from double negative (DN) to DP cells. Accelerated maturation is observed in mice injected with anti-CD3 to mimic pre-T-cell receptor stimulation, and also in mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide to induce EAE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1096-0945
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20599940-Animals,
pubmed-meshheading:20599940-Antigens, CD3,
pubmed-meshheading:20599940-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20599940-Cells, Cultured,
pubmed-meshheading:20599940-Disease Susceptibility,
pubmed-meshheading:20599940-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:20599940-Female,
pubmed-meshheading:20599940-Interleukin-12,
pubmed-meshheading:20599940-Lymphocyte Activation,
pubmed-meshheading:20599940-Mice,
pubmed-meshheading:20599940-Mice, Knockout,
pubmed-meshheading:20599940-Myelin Proteins,
pubmed-meshheading:20599940-Myelin-Associated Glycoprotein,
pubmed-meshheading:20599940-Thymus Gland
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pubmed:year |
2010
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pubmed:articleTitle |
Accelerated thymocyte maturation in IL-12R?2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination.
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pubmed:affiliation |
Department of Neurology, Thomas Jefferson University, 300 JHN Building, 900 Walnut Street, Philadelphia, PA 19107, USA. bruno.gran@nottingham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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