Linked Life Data

20599428

Source:http://linkedlifedata.com/resource/pubmed/id/20599428

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-8-23
pubmed:abstractText
Detailed organization of interlaminar relations in neuronal activity underlying recent and remote memory recall is unknown but essential for deciphering interlaminar connections involved in systems-level memory consolidation and permanent information storage. We mapped Arc/Arg3.1 (Arc) mRNA expression, a neuronal activity marker, at multiple rostro-caudal levels of the brain in Wistar rats following a platform search in a water-maze task. Strength of interlaminar correlations in Arc expression and modulation of the strength by memory recall in sensory, motor and association cortical areas were measured at 24h and 1 month in memory retention. In order to estimate the extent of modular organization in neocortical function underlying memory recall, we studied multiple profiles of interlaminar coupling. At the level of cortical areas, we captured two robust stereotypical laminar patterns for distribution of strong and weak interlaminar correlations. These patterns emerged during both control swimming and navigation, at both retention delays. Within limits of these patterns, we established task-, time- and area-dependent modulations of the Arc correlations. Relative to swimming control, during memory recall, changes in strength of analogous interlaminar relations occurred largely in parallel but recent and remote recall modulated mostly distinct correlations. An effective remote memory recall was accompanied by fewer strengthened correlations as compared to recent recall. Thus, a behavioral experience is accompanied by a well-ordered or stereotypical spatial organization of interlaminar relations in neuronal activity distribution. Interlaminar correlations in Arc expression modulated by recent and remote memory recall could guide future inactivation and detection studies necessary to decipher interlaminar connections involved in systems-level consolidation and to reveal mnemonic plasticity specific to spatial memory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1872-6240
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
1352
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-39
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Recent and remote memory recalls modulate different sets of stereotypical interlaminar correlations in Arc/Arg3.1 mRNA expression in cortical areas.
pubmed:affiliation
Blanchette Rockefeller Neurosciences Institute, Rockville, MD 20850, USA. pgusev@usuhs.mil
pubmed:publicationType
Journal Article