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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-8-2
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pubmed:databankReference |
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pubmed:abstractText |
Dopamine D(3) receptors are involved in the pathophysiology of several neuropsychiatric conditions. [(11)C]-(+)-PHNO is a radiolabeled D(2) and D(3) agonist, suitable for imaging the agonist binding sites (denoted D(2HIGH) and D(3)) of these receptors with positron emission tomography (PET). PET studies in nonhuman primates documented that, in vivo, [(11)C]-(+)-PHNO displays a relative selectivity for D(3) compared with D(2HIGH) receptor sites and that the [(11)C]-(+)-PHNO signal is enriched in D(3) contribution compared with conventional ligands such as [(11)C] raclopride.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-2402
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pubmed:author |
pubmed-author:BaniMassimoM,
pubmed-author:BeaverJohn DJD,
pubmed-author:ComleyRobert ARA,
pubmed-author:GriffanteCristianaC,
pubmed-author:GunnRogerR,
pubmed-author:HouleSylvainS,
pubmed-author:LaruelleMarcM,
pubmed-author:Merlo-PichEmilioE,
pubmed-author:MugnainiManoloM,
pubmed-author:RabinerEugenii AEA,
pubmed-author:SearleGrahamG,
pubmed-author:SlifsteinMarkM,
pubmed-author:TziortziAndriA,
pubmed-author:WilsonAlan AAA
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pubmed:copyrightInfo |
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
392-9
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pubmed:meshHeading |
pubmed-meshheading:20599188-Adult,
pubmed-meshheading:20599188-Binding, Competitive,
pubmed-meshheading:20599188-Brain,
pubmed-meshheading:20599188-Brain Mapping,
pubmed-meshheading:20599188-Carbon Radioisotopes,
pubmed-meshheading:20599188-Dopamine Agonists,
pubmed-meshheading:20599188-Dopamine Antagonists,
pubmed-meshheading:20599188-Dose-Response Relationship, Drug,
pubmed-meshheading:20599188-Humans,
pubmed-meshheading:20599188-Oxadiazoles,
pubmed-meshheading:20599188-Oxazines,
pubmed-meshheading:20599188-Positron-Emission Tomography,
pubmed-meshheading:20599188-Receptors, Dopamine D3,
pubmed-meshheading:20599188-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist.
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pubmed:affiliation |
Clinical Imaging Centre, GlaxoSmithKline, London, United Kingdom. graham.e.searle@gsk.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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