Linked Life Data

20598676

Source:http://linkedlifedata.com/resource/pubmed/id/20598676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19-20
pubmed:dateCreated
2010-7-26
pubmed:abstractText
Although the role of histone acetylation in gene regulation has been the subject of many reviews, their impact on cell physiology and pathological states of proliferation, differentiation and genome stability in eukaryotic cells remain to be elucidated. Therefore, this review will discuss the molecular, physiological and biochemical aspects of histone acetylation and focus on the interplay of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in different disease states. Current treatment strategies are mostly limited to enzyme inhibitors, though potential lies in targeting other imperative chromatin remodeling factors involved in gene regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-3492
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
411
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1401-11
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Role of histone acetylation in cell physiology and diseases: An update.
pubmed:affiliation
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't