|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2010-7-28
|
|
pubmed:abstractText |
Mutation analysis of KIT and PDGFRA genes in gastrointestinal stromal tumors is gaining increasing importance for prognosis of GISTs and for prediction of treatment response. Several groups have identified specific mutational subtypes in KIT exon 11 associated with an increased risk of metastatic disease whereas GISTs with PDGFRA mutations often behave less aggressive. Furthermore, in advanced GIST disease with proven KIT exon 9 mutation the doubled daily dose of 800 mg imatinib increases the progression free survival and is now recommended both in the European and the American Guidelines. In Germany, there are still no general rules how to perform mutational analysis.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-10612815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-11172303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-12466110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-12918066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-12960119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-14645423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-14691917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-15146165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-15166276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-15269295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-15795882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-15928335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-16135486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-16258521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-16287112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-1650795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-16624552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-17193820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-17298867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-17624289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-17701051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-18312355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-18525339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-18794084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-18955451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-19110398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-3009004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-3194201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20598160-9137080
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2350
|
|
pubmed:author |
pubmed-author:DietmaierWolfgangW,
pubmed-author:FüzesiLaszloL,
pubmed-author:GaumannAndreasA,
pubmed-author:HallerFlorianF,
pubmed-author:KitzJuliaJ,
pubmed-author:KrohnAntjeA,
pubmed-author:MechtersheimerGunhildG,
pubmed-author:Merkelbach-BruseSabineS,
pubmed-author:PenzelRolandR,
pubmed-author:SchildhausHans-UlrichHU,
pubmed-author:Schneider-StockRegineR,
pubmed-author:SimonRonaldR,
pubmed-author:WardelmannEvaE
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
106
|
|
pubmed:dateRevised |
2011-4-8
|
|
pubmed:meshHeading |
pubmed-meshheading:20598160-DNA Mutational Analysis,
pubmed-meshheading:20598160-Disease-Free Survival,
pubmed-meshheading:20598160-Exons,
pubmed-meshheading:20598160-Gastrointestinal Stromal Tumors,
pubmed-meshheading:20598160-Germany,
pubmed-meshheading:20598160-Humans,
pubmed-meshheading:20598160-Mutation,
pubmed-meshheading:20598160-Piperazines,
pubmed-meshheading:20598160-Prognosis,
pubmed-meshheading:20598160-Pyrimidines,
pubmed-meshheading:20598160-Receptor, Platelet-Derived Growth Factor alpha
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors.
|
|
pubmed:affiliation |
Department of Pathology, University of Bonn Medical School, Sigmund-Freud-Str, 25 D-53127 Bonn, Germany. sabine.merkelbach-bruse@ukb.uni-bonn.de
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
