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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-7-2
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pubmed:abstractText |
Accumulation of plasma advanced oxidation protein products (AOPPs) promotes progression of proteinuria and glomerulosclerosis. To investigate the molecular basis of AOPPs-induced proteinuria, normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin. The expression of glomerular podocyte slit diaphragm (PSD)-associated proteins, nephrin and podocin, was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs. Chronic inhibition of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats. This suggested that accumulation of AOPPs promotes proteinuria, possibly via down-regulating the expression of PSD-associated proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1869-1889
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-77
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pubmed:meshHeading |
pubmed-meshheading:20596957-Animals,
pubmed-meshheading:20596957-Blotting, Western,
pubmed-meshheading:20596957-Cells, Cultured,
pubmed-meshheading:20596957-Dose-Response Relationship, Drug,
pubmed-meshheading:20596957-Gene Expression,
pubmed-meshheading:20596957-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20596957-Kidney Glomerulus,
pubmed-meshheading:20596957-Male,
pubmed-meshheading:20596957-Membrane Proteins,
pubmed-meshheading:20596957-Mice,
pubmed-meshheading:20596957-Oxidation-Reduction,
pubmed-meshheading:20596957-Podocytes,
pubmed-meshheading:20596957-Proteins,
pubmed-meshheading:20596957-Proteinuria,
pubmed-meshheading:20596957-Rats,
pubmed-meshheading:20596957-Rats, Sprague-Dawley,
pubmed-meshheading:20596957-Reactive Oxygen Species,
pubmed-meshheading:20596957-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20596957-Serum Albumin,
pubmed-meshheading:20596957-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK.
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pubmed:affiliation |
Key Laboratory for organ failure research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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