Linked Life Data

20596937

Source:http://linkedlifedata.com/resource/pubmed/id/20596937

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-7-2
pubmed:abstractText
Sexual dimorphism definitely exists in the pathogenesis of a variety of cardiovascular, neurodegenerative and bone metabolism disorders. Estrogen affects the healing of ischemic myocardium partially through paracrine growth hormone production by bone marrow mesenchymal stem cells (MSCs) and facilitation on mobilization of endothelial progenitors cells (EPCs) to the ischemic myocardium. Estrogen can also inhibit the proliferation of the cardiac fibroblasts. Therefore, estrogen effectively enhances the neovascularization at the ischemic border zone and limits pathological myocardial remodeling. Moreover, estrogen increases proliferation of embryonic neural stem cells and accelerates differentiation of neurons during neurogenesis, suggesting a possible role of estrogen in transplantation of neural stem cells as a therapeutic approach for neurodegenerative diseases. Finally, estrogen can modulate osteogenic progenitors and osteoclasts, preventing the osteoporosis. In general, estrogen offers significant benefits on diverse stem/progenitor cell populations. A great understanding of estrogens on these cells and relevant intracellular mechanisms will allow modulation of the potent stem cells directly for the ultimate clinical applications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1869-1889
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
542-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effects of estrogen on diverse stem cells and relevant intracellular mechanisms.
pubmed:affiliation
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. hysun@sjtu.edu.cn
pubmed:publicationType
Journal Article, Review