| pubmed-article:20596670 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0242608 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0971285 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C1155781 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:20596670 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20596670 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20596670 | pubmed:dateCreated | 2010-7-2 | lld:pubmed |
| pubmed-article:20596670 | pubmed:abstractText | Aurora-A is involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and regards to an oncogene. Aurora-A is also known to bind to several other proteins affecting its up-regulation or down-regulation and localization. However, how these different binding signals work together to regulate Aurora-A is not properly known. To explore more Aurora-A interacting proteins, the low-copy yeast two-hybrid screening using Aurora-A as bait protein was performed. One novel gene, AIBp, was demonstrated to associate with Aurora-A by the yeast two-hybrid method and in vitro GST pull-down assay. Molecular characterization showed that AIBp possessed a binding site at the C-terminal with Aurora-A (kinase domain). Interestingly, AIBp also interacts with hNinein at the N-terminal, which overlaps with a previously reported hNinein and GSK3beta binding site. Using a kinase assay, AIBp interacts with the Aurora-A kinase domain functions as a positive regulator, whereas AIBp binding to hNinein appears to block the phosphorylation of hNinein by both Aurora-A and GSK3beta. siRNA-mediated elimination of AIBp from HeLa cells, results in a doughnut-like shape, asymmetrical spindle pole and multiple spindle pole formation. We also demonstrated that both AIBp and Aurora-A are co-overexpressed in various brain tumors. These studies demonstrate that AIBp may not only be required for the dynamic movement of Aurora-A at the centrosomes and spindle apparatus during the cell cycle, but may also be important during brain tumorigenesis. | lld:pubmed |
| pubmed-article:20596670 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20596670 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20596670 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20596670 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20596670 | pubmed:issn | 1791-2423 | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:WuChia-HungCH | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:HowngShen-Lon... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:HsuChing-MeiC... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:ChengTai-Shan... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:HongYi-RenYR | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:HuangChi-Ying... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:LohJoon-KhimJ... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:LieuAnn-Shung... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:ChangLi-KwanL... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:HsuChia-YiCY | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:ChouChia-HuaC... | lld:pubmed |
| pubmed-article:20596670 | pubmed:author | pubmed-author:ChangChung-Sh... | lld:pubmed |
| pubmed-article:20596670 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20596670 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:20596670 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20596670 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20596670 | pubmed:pagination | 429-36 | lld:pubmed |
| pubmed-article:20596670 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
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| pubmed-article:20596670 | pubmed:meshHeading | pubmed-meshheading:20596670... | lld:pubmed |
| pubmed-article:20596670 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20596670 | pubmed:articleTitle | Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. | lld:pubmed |
| pubmed-article:20596670 | pubmed:affiliation | Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC. | lld:pubmed |
| pubmed-article:20596670 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20596670 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:79000 | entrezgene:pubmed | pubmed-article:20596670 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20596670 | lld:entrezgene |
