pubmed-article:20596645 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0205169 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C1366450 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C1826257 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:20596645 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
pubmed-article:20596645 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:20596645 | pubmed:dateCreated | 2010-7-2 | lld:pubmed |
pubmed-article:20596645 | pubmed:abstractText | BAD (BCL-2 antagonist of cell death) is a pro-apoptotic BCL-2 family protein that plays a critical role in the regulation of apoptotic response. This study presents direct evidence that AF1q increased the radiation-induced apoptosis through up-regulation of BAD in human squamous carcinoma A431 cells and the key transcription factor involved is NF-kappaB. The minimal promoter sequence of BAD was identified; the activity was increased in AF1q stable transfectants and decreased upon AF1q siRNA transfection. The NF-kappaB consensus binding sequence is detected on BAD promoter. Inactivation of NF-kappaB by NF-kappaB inhibitor Bay 11-7082 or NF-kappaB p65 siRNA suppressed the expression and promoter activity of BAD; the suppression is more obvious in AF1q stable transfectants which also have an elevated NF-kappaB level. Mutation of putative NF-kappaB motif decreased the BAD promoter activity. The binding of NF-kappaB to the BAD promoter was confirmed by chromatin-immunoprecipitation. These findings indicate that AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. | lld:pubmed |
pubmed-article:20596645 | pubmed:language | eng | lld:pubmed |
pubmed-article:20596645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20596645 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20596645 | pubmed:month | Aug | lld:pubmed |
pubmed-article:20596645 | pubmed:issn | 1791-2431 | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:TsangWing... | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:CoNgai NaNN | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:TsangTsun... | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:KwokTim TakTT | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:KongSiu KaiSK | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:YeungChi... | lld:pubmed |
pubmed-article:20596645 | pubmed:author | pubmed-author:YauPak LunPL | lld:pubmed |
pubmed-article:20596645 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20596645 | pubmed:volume | 24 | lld:pubmed |
pubmed-article:20596645 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20596645 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20596645 | pubmed:pagination | 547-54 | lld:pubmed |
pubmed-article:20596645 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:meshHeading | pubmed-meshheading:20596645... | lld:pubmed |
pubmed-article:20596645 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:20596645 | pubmed:articleTitle | AF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous carcinoma A431 cells. | lld:pubmed |
pubmed-article:20596645 | pubmed:affiliation | Faculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, PR China. | lld:pubmed |
pubmed-article:20596645 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:20596645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:572 | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |
entrez-gene:5970 | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |
entrez-gene:10962 | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20596645 | lld:entrezgene |