Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20596645rdf:typepubmed:Citationlld:pubmed
pubmed-article:20596645lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0007634lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0007137lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0162638lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0079904lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0041904lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0205169lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0162493lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C1366450lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C1823153lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C1826257lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C2349976lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C1552644lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C2349975lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:20596645lifeskim:mentionsumls-concept:C1627358lld:lifeskim
pubmed-article:20596645pubmed:issue2lld:pubmed
pubmed-article:20596645pubmed:dateCreated2010-7-2lld:pubmed
pubmed-article:20596645pubmed:abstractTextBAD (BCL-2 antagonist of cell death) is a pro-apoptotic BCL-2 family protein that plays a critical role in the regulation of apoptotic response. This study presents direct evidence that AF1q increased the radiation-induced apoptosis through up-regulation of BAD in human squamous carcinoma A431 cells and the key transcription factor involved is NF-kappaB. The minimal promoter sequence of BAD was identified; the activity was increased in AF1q stable transfectants and decreased upon AF1q siRNA transfection. The NF-kappaB consensus binding sequence is detected on BAD promoter. Inactivation of NF-kappaB by NF-kappaB inhibitor Bay 11-7082 or NF-kappaB p65 siRNA suppressed the expression and promoter activity of BAD; the suppression is more obvious in AF1q stable transfectants which also have an elevated NF-kappaB level. Mutation of putative NF-kappaB motif decreased the BAD promoter activity. The binding of NF-kappaB to the BAD promoter was confirmed by chromatin-immunoprecipitation. These findings indicate that AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer.lld:pubmed
pubmed-article:20596645pubmed:languageenglld:pubmed
pubmed-article:20596645pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:citationSubsetIMlld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20596645pubmed:statusMEDLINElld:pubmed
pubmed-article:20596645pubmed:monthAuglld:pubmed
pubmed-article:20596645pubmed:issn1791-2431lld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:TsangWing...lld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:CoNgai NaNNlld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:TsangTsun...lld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:KwokTim TakTTlld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:KongSiu KaiSKlld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:YeungChi...lld:pubmed
pubmed-article:20596645pubmed:authorpubmed-author:YauPak LunPLlld:pubmed
pubmed-article:20596645pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20596645pubmed:volume24lld:pubmed
pubmed-article:20596645pubmed:ownerNLMlld:pubmed
pubmed-article:20596645pubmed:authorsCompleteYlld:pubmed
pubmed-article:20596645pubmed:pagination547-54lld:pubmed
pubmed-article:20596645pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:meshHeadingpubmed-meshheading:20596645...lld:pubmed
pubmed-article:20596645pubmed:year2010lld:pubmed
pubmed-article:20596645pubmed:articleTitleAF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous carcinoma A431 cells.lld:pubmed
pubmed-article:20596645pubmed:affiliationFaculty of Medicine, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, PR China.lld:pubmed
pubmed-article:20596645pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20596645pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:572entrezgene:pubmedpubmed-article:20596645lld:entrezgene
entrez-gene:5970entrezgene:pubmedpubmed-article:20596645lld:entrezgene
entrez-gene:10962entrezgene:pubmedpubmed-article:20596645lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:20596645lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:20596645lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:20596645lld:entrezgene