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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-9-15
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pubmed:abstractText |
The role of retinoblastoma protein-interacting zinc finger 1 (RIZ1) on the cell growth of mouse and human monocytic leukemia cells was examined. RIZ1 expression was induced in response to tumor necrosis factor (TNF)-?. The expression was dependent on the nuclear factor-?B and AKT signaling. Further, RIZ1 expression led to the augmentation of p53 expression and the silencing of RIZ1 prevented it. On the other hand, a p53 inhibitor enhanced the TNF-?-induced RIZ1 expression. Silencing of RIZ1 augmented the proliferative activity of TNF-?-treated cells. Therefore, it is suggested that RIZ1 negatively regulated the cell proliferation of monocytic leukemia cells via activation of p53.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1532-4192
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
806-12
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pubmed:meshHeading |
pubmed-meshheading:20594067-Animals,
pubmed-meshheading:20594067-Cell Division,
pubmed-meshheading:20594067-DNA Methylation,
pubmed-meshheading:20594067-DNA Primers,
pubmed-meshheading:20594067-DNA-Binding Proteins,
pubmed-meshheading:20594067-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20594067-Gene Silencing,
pubmed-meshheading:20594067-Histone-Lysine N-Methyltransferase,
pubmed-meshheading:20594067-Homeostasis,
pubmed-meshheading:20594067-Humans,
pubmed-meshheading:20594067-Leukemia, Myeloid,
pubmed-meshheading:20594067-Mice,
pubmed-meshheading:20594067-Neoplasms,
pubmed-meshheading:20594067-Nuclear Proteins,
pubmed-meshheading:20594067-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20594067-Transcription Factors,
pubmed-meshheading:20594067-Transfection,
pubmed-meshheading:20594067-Tumor Necrosis Factor-alpha,
pubmed-meshheading:20594067-Tumor Suppressor Protein p53
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pubmed:year |
2010
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pubmed:articleTitle |
Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53.
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pubmed:affiliation |
Department of Microbiology and Immunology, School of Medicine, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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