Source:http://linkedlifedata.com/resource/pubmed/id/20593838
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2010-8-6
|
| pubmed:abstractText |
Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1520-6025
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
23
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1301-5
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| pubmed:meshHeading |
pubmed-meshheading:20593838-Diterpenes,
pubmed-meshheading:20593838-Drug Screening Assays, Antitumor,
pubmed-meshheading:20593838-Drugs, Chinese Herbal,
pubmed-meshheading:20593838-Euphorbiaceae,
pubmed-meshheading:20593838-HL-60 Cells,
pubmed-meshheading:20593838-Humans,
pubmed-meshheading:20593838-Molecular Structure,
pubmed-meshheading:20593838-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:20593838-Phenanthrenes,
pubmed-meshheading:20593838-Plant Stems
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.
|
| pubmed:affiliation |
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|