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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-7-1
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pubmed:abstractText |
Genes encoding for cytokines have been associated with susceptibility for joint osteoarthritis (OA) and interleukin (IL)-1 gene is supposed to be involved in the cartilage destruction process. In this regard, interleukin-1 receptor antagonist (IL-1RA) competing with IL-1 for binding to its receptor may act as an inhibitor of cartilage breakdown. We assessed the association of primary knee OA with IL-1RA region as a putative factor of susceptibility to knee OA in Egyptian patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1875-8630
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-305
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pubmed:dateRevised |
2010-11-15
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pubmed:meshHeading |
pubmed-meshheading:20592454-Antirheumatic Agents,
pubmed-meshheading:20592454-Case-Control Studies,
pubmed-meshheading:20592454-Egypt,
pubmed-meshheading:20592454-Female,
pubmed-meshheading:20592454-Gene Frequency,
pubmed-meshheading:20592454-Genetic Predisposition to Disease,
pubmed-meshheading:20592454-Genotype,
pubmed-meshheading:20592454-Humans,
pubmed-meshheading:20592454-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:20592454-Interleukin-1,
pubmed-meshheading:20592454-Introns,
pubmed-meshheading:20592454-Male,
pubmed-meshheading:20592454-Middle Aged,
pubmed-meshheading:20592454-Osteoarthritis, Knee,
pubmed-meshheading:20592454-Polymerase Chain Reaction,
pubmed-meshheading:20592454-Polymorphism, Genetic,
pubmed-meshheading:20592454-Risk Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Potential influence of interleukin-1 receptor antagonist gene polymorphism on knee osteoarthritis risk.
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pubmed:affiliation |
Department of Biochemistry, National Research Center, Dokki, Giza, Egypt. swellam@hotmail.com <swellam@hotmail.com>
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pubmed:publicationType |
Journal Article,
Comparative Study
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