|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-9-16
|
|
pubmed:abstractText |
We report here the first direct measurements of persistent inward currents (PICs) in rat hindlimb motoneurons, obtained from ketamine-xylazine anesthetized rats during slow voltage ramps performed by single-electrode somatic voltage clamp. Most motoneurons expressed PICs and current-voltage (I-V) relations often contained a negative-slope region (NSR; 13/19 cells). PICs activated at -52.7 ± 3.89 mV, 9 mV negative to spike threshold. NSR onset was -44.2 ± 4.1 mV. PIC amplitudes were assessed by maximum inward currents measured relative to extrapolated leak current and to NSR-onset current. PIC conductance at potentials just positive to activation was assessed by the relative change in slope conductance (g(in)/g(leak)). PIC amplitudes varied widely; some exceeded 5 and 10 nA relative to current at NSR onset or leak current, respectively. PIC amplitudes did not vary significantly with input conductance, but PIC amplitudes normalized by recruitment current decreased with increasing input conductance. Similarly, g(in)/g(leak) decreased with increasing input conductance. Currents near resting potential on descending limbs of I-V relations were often outward, relative to ascending-limb currents. This residual outward current was correlated with increases in leak conductance on the descending limb and with input conductance. Excluding responses with accommodation, residual outward currents matched differences between recruitment and derecruitment currents, suggesting a role for residual outward current in frequency adaptation. Comparison of potentials for PIC activation and NSR onset with interspike trajectories during discharge demonstrated correspondence between PIC activation and frequency-current (f-I) range boundaries. Contributions of persistent inward and outward currents to motoneuron discharge characteristics are discussed.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-10561423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-10964980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-11252765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-11600653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-11986376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-12522206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-12724367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-14762142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-14762149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16367775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16525039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16613880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16707714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16709627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-16760346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-17079337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-17158244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-17287343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-17360829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-17522175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-18006586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-19412167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-20592119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-6324889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-6965523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-7143033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-9003557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-9310460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-9705451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20592117-9705452
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1522-1598
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1566-77
|
|
pubmed:dateRevised |
2011-9-13
|
|
pubmed:meshHeading |
pubmed-meshheading:20592117-Action Potentials,
pubmed-meshheading:20592117-Animals,
pubmed-meshheading:20592117-Female,
pubmed-meshheading:20592117-Hindlimb,
pubmed-meshheading:20592117-Male,
pubmed-meshheading:20592117-Membrane Potentials,
pubmed-meshheading:20592117-Motor Neurons,
pubmed-meshheading:20592117-Rats,
pubmed-meshheading:20592117-Rats, Long-Evans,
pubmed-meshheading:20592117-Time Factors
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Persistent currents and discharge patterns in rat hindlimb motoneurons.
|
|
pubmed:affiliation |
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Division of Neurobiology, 350 W. Thomas Rd., Phoenix, AZ 85013, USA. Thomas.Hamm@chw.edu
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
