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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-7-13
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pubmed:abstractText |
Analogues of the novel inhibitor of the PI3-K/PKB pathway, 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate (E1), have been prepared and preliminary SAR performed. This established that at least one of the chloroethyl para-substituents could be removed or modified and the ability to inhibit PKB/Akt activation retained. Synthetic methodologies were then developed to methylene-linked aryl acetates for use as molecular probes to identify the target of compound E1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4917-27
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pubmed:meshHeading |
pubmed-meshheading:20591679-Antineoplastic Agents,
pubmed-meshheading:20591679-Breast Neoplasms,
pubmed-meshheading:20591679-Cell Line, Tumor,
pubmed-meshheading:20591679-Enzyme Inhibitors,
pubmed-meshheading:20591679-Female,
pubmed-meshheading:20591679-Humans,
pubmed-meshheading:20591679-Phenylacetates,
pubmed-meshheading:20591679-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20591679-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20591679-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Development of chemical probes: toward the mode of action of a methylene-linked di(aryl acetate) E1.
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pubmed:affiliation |
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, UK.
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pubmed:publicationType |
Journal Article
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