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pubmed-article:20591663pubmed:abstractTextThe pharmacophore model of in house potent and selective alpha7 nAChR positive allosteric modulators is reported. The model was used to fish out commercially-available compounds from corporate 3D databases. As a result, novel alpha7 positive modulator chemotypes were identified. A rat full PK profile of a representative compound is also described.lld:pubmed
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pubmed-article:20591663pubmed:copyrightInfoCopyright 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20591663pubmed:articleTitleIdentification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.lld:pubmed
pubmed-article:20591663pubmed:affiliationGlaxoSmithKline, Molecular Discovery Research, Verona, Italy. Anna-Maria.M.Capelli@gsk.comlld:pubmed
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