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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2010-7-16
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pubmed:abstractText |
The pharmacophore model of in house potent and selective alpha7 nAChR positive allosteric modulators is reported. The model was used to fish out commercially-available compounds from corporate 3D databases. As a result, novel alpha7 positive modulator chemotypes were identified. A rat full PK profile of a representative compound is also described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4561-5
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pubmed:meshHeading |
pubmed-meshheading:20591663-Allosteric Regulation,
pubmed-meshheading:20591663-Animals,
pubmed-meshheading:20591663-Cell Line,
pubmed-meshheading:20591663-Databases, Factual,
pubmed-meshheading:20591663-Humans,
pubmed-meshheading:20591663-Isoxazoles,
pubmed-meshheading:20591663-Microsomes, Liver,
pubmed-meshheading:20591663-Models, Molecular,
pubmed-meshheading:20591663-Phenylurea Compounds,
pubmed-meshheading:20591663-Rats,
pubmed-meshheading:20591663-Receptors, Nicotinic,
pubmed-meshheading:20591663-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.
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pubmed:affiliation |
GlaxoSmithKline, Molecular Discovery Research, Verona, Italy. Anna-Maria.M.Capelli@gsk.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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