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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-12-20
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pubmed:abstractText |
Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-1781
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286-9
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pubmed:meshHeading |
pubmed-meshheading:20591499-Adolescent,
pubmed-meshheading:20591499-Adult,
pubmed-meshheading:20591499-Analysis of Variance,
pubmed-meshheading:20591499-Antipsychotic Agents,
pubmed-meshheading:20591499-Catechol O-Methyltransferase,
pubmed-meshheading:20591499-DNA Mutational Analysis,
pubmed-meshheading:20591499-Double-Blind Method,
pubmed-meshheading:20591499-Female,
pubmed-meshheading:20591499-Gene Frequency,
pubmed-meshheading:20591499-Genotype,
pubmed-meshheading:20591499-Humans,
pubmed-meshheading:20591499-Longitudinal Studies,
pubmed-meshheading:20591499-Male,
pubmed-meshheading:20591499-Methionine,
pubmed-meshheading:20591499-Middle Aged,
pubmed-meshheading:20591499-Pharmacogenetics,
pubmed-meshheading:20591499-Polymorphism, Genetic,
pubmed-meshheading:20591499-Psychiatric Status Rating Scales,
pubmed-meshheading:20591499-Psychotic Disorders,
pubmed-meshheading:20591499-Regression Analysis,
pubmed-meshheading:20591499-Treatment Outcome,
pubmed-meshheading:20591499-Valine,
pubmed-meshheading:20591499-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis.
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pubmed:affiliation |
Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla-IFIMAV, School of Medicine, University of Cantabria, Santander, Spain.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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