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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-7-1
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pubmed:abstractText |
There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 and 3A], due to genetic polymorphisms and/or drug-drug interactions. The effects of CYP2D6 and/or CYP3A activity modulation on the pharmacokinetics of oxycodone remains poorly explored.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-15039299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-15114429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-15625333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-16189332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-16414038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-16678548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-16717324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-17259947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-1851921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-18591960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-18836708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-19417618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-19883461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-20590588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-6194952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-7996467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-8492004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-8549034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-8819499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-8971431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-9051543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-9352573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20590587-9871425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2D6,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoconazole,
http://linkedlifedata.com/resource/pubmed/chemical/Oxycodone,
http://linkedlifedata.com/resource/pubmed/chemical/Quinidine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
907-18
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20590587-Adult,
pubmed-meshheading:20590587-Analgesics, Opioid,
pubmed-meshheading:20590587-Cross-Over Studies,
pubmed-meshheading:20590587-Cytochrome P-450 CYP2D6,
pubmed-meshheading:20590587-Cytochrome P-450 CYP3A,
pubmed-meshheading:20590587-Double-Blind Method,
pubmed-meshheading:20590587-Drug Interactions,
pubmed-meshheading:20590587-Enzyme Inhibitors,
pubmed-meshheading:20590587-Genotype,
pubmed-meshheading:20590587-Humans,
pubmed-meshheading:20590587-Ketoconazole,
pubmed-meshheading:20590587-Male,
pubmed-meshheading:20590587-Metabolic Detoxication, Phase I,
pubmed-meshheading:20590587-Oxycodone,
pubmed-meshheading:20590587-Phenotype,
pubmed-meshheading:20590587-Polymorphism, Genetic,
pubmed-meshheading:20590587-Quinidine,
pubmed-meshheading:20590587-Receptors, Opioid, mu,
pubmed-meshheading:20590587-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone.
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pubmed:affiliation |
Clinical Pharmacology and Toxicology and Multidisciplinary Pain Centre, Department of Anaesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, Switzerland. Caroline.Samer@hcuge.ch
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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