|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0015780,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0080178,
umls-concept:C0152426,
umls-concept:C0181586,
umls-concept:C0185117,
umls-concept:C0266453,
umls-concept:C0439750,
umls-concept:C1537677,
umls-concept:C2911684
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2010-8-26
|
|
pubmed:abstractText |
A precise temporal and spatial regulation of gene expression is necessary to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind transcription factors and modulate expression of their target genes. Med12 is essential during early mouse development and is important for neural tube closure.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1542-0760
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
88
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
626-32
|
|
pubmed:meshHeading |
pubmed-meshheading:20589884-Animals,
pubmed-meshheading:20589884-Female,
pubmed-meshheading:20589884-Gene Expression Regulation, Developmental,
pubmed-meshheading:20589884-Mediator Complex,
pubmed-meshheading:20589884-Mice,
pubmed-meshheading:20589884-Mice, Inbred C57BL,
pubmed-meshheading:20589884-Mosaicism,
pubmed-meshheading:20589884-Neural Tube Defects,
pubmed-meshheading:20589884-Pregnancy,
pubmed-meshheading:20589884-Spinal Dysraphism
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis.
|
|
pubmed:affiliation |
Institute of Medical Genetics, Charité University of Medicine-Berlin, Berlin, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
