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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-10-27
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pubmed:abstractText |
Alkylating agents are commonly used in the treatment of childhood malignant gliomas. Overexpression of O(6)-methylguanine-DNA methyltransferase (MGMT) constitutes an important mechanism for resistance to such agents, and MGMT status has been associated with outcome in several recent trials. Deficiency in mismatch repair (MMR) function has been implicated in preclinical studies as an additional potential mechanism of resistance to methylating agents, such as temozolomide, independent of tumor MGMT status. However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1545-5017
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pubmed:author |
pubmed-author:BratDaniel JDJ,
pubmed-author:BurgerPeter CPC,
pubmed-author:Children's Oncology Group,
pubmed-author:CohenKenneth JKJ,
pubmed-author:FinlayJonathan LJL,
pubmed-author:GillesFloyd HFH,
pubmed-author:HamiltonRonald LRL,
pubmed-author:JakackiRegina IRI,
pubmed-author:LaFramboiseWilliam AWA,
pubmed-author:Lyons-WeilerMaureen AMA,
pubmed-author:NikiforovYuri EYE,
pubmed-author:NikiforovaMarina NMN,
pubmed-author:PollackIan FIF,
pubmed-author:RosenblumMarc KMK,
pubmed-author:SobolRobert WRW,
pubmed-author:YatesAllan JAJ,
pubmed-author:ZhouTianniT
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1066-71
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20589656-Antineoplastic Agents, Alkylating,
pubmed-meshheading:20589656-Child,
pubmed-meshheading:20589656-DNA Mismatch Repair,
pubmed-meshheading:20589656-Dacarbazine,
pubmed-meshheading:20589656-Drug Resistance, Neoplasm,
pubmed-meshheading:20589656-Glioma,
pubmed-meshheading:20589656-Humans,
pubmed-meshheading:20589656-Microsatellite Instability,
pubmed-meshheading:20589656-Microsatellite Repeats,
pubmed-meshheading:20589656-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:20589656-Prognosis
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pubmed:year |
2010
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pubmed:articleTitle |
Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group.
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pubmed:affiliation |
Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ian.pollack@chp.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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