Linked Life Data

20588505

Source:http://linkedlifedata.com/resource/pubmed/id/20588505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2010-6-30
pubmed:abstractText
We propose and demonstrate the use of subharmonically synchronized laser pulses for low-noise lock-in detection in stimulated Raman scattering (SRS) microscopy. In the experiment, Yb-fiber laser pulses at a repetition rate of 38 MHz are successfully synchronized to Ti:sapphire laser pulses at a repetition rate of 76 MHz with a jitter of <8 fs by a two-photon detector and an intra-cavity electro-optic modulator. By using these pulses, high-frequency lock-in detection of SRS signal is accomplished without high-speed optical modulation. The noise level of the lock-in signal is found to be higher than the shot noise limit only by 1.6 dB. We also demonstrate high-contrast, 3D imaging of unlabeled living cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1094-4087
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13708-19
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Stimulated Raman scattering microscope with shot noise limited sensitivity using subharmonically synchronized laser pulses.
pubmed:affiliation
Department of Material and Life Science, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan. ozeki@mls.eng.osaka-u.ac.jp
pubmed:publicationType
Journal Article