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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022646,
umls-concept:C0042666,
umls-concept:C0185117,
umls-concept:C0240035,
umls-concept:C0332208,
umls-concept:C0443252,
umls-concept:C0450127,
umls-concept:C0542341,
umls-concept:C1332712,
umls-concept:C1858395,
umls-concept:C2911684
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pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-9-3
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|
pubmed:abstractText |
Development of interstitial fibrosis and tubular atrophy (IF/TA) is the main histologic feature involved in renal allograft deterioration. The aim of this study was to validate whether de novo tubular expression of CD44 (transmembrane glycoprotein) and vimentin (mesenchymal cell marker), both involved in renal fibrosis, can operate as surrogate markers for late IF/TA and renal function. Furthermore, we wanted to establish the interrater reproducibility for the scoring system, which can be a problem in histologic assessments.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1534-6080
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
90
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
502-9
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pubmed:meshHeading |
pubmed-meshheading:20588206-Adult,
pubmed-meshheading:20588206-Antibodies, Monoclonal,
pubmed-meshheading:20588206-Antigens, CD44,
pubmed-meshheading:20588206-Atrophy,
pubmed-meshheading:20588206-Biopsy,
pubmed-meshheading:20588206-Female,
pubmed-meshheading:20588206-Fibrosis,
pubmed-meshheading:20588206-Glomerular Filtration Rate,
pubmed-meshheading:20588206-Graft Survival,
pubmed-meshheading:20588206-Humans,
pubmed-meshheading:20588206-Immunohistochemistry,
pubmed-meshheading:20588206-Immunosuppressive Agents,
pubmed-meshheading:20588206-Kidney Function Tests,
pubmed-meshheading:20588206-Kidney Transplantation,
pubmed-meshheading:20588206-Kidney Tubules,
pubmed-meshheading:20588206-Male,
pubmed-meshheading:20588206-Postoperative Complications,
pubmed-meshheading:20588206-Prospective Studies,
pubmed-meshheading:20588206-Transplantation, Homologous,
pubmed-meshheading:20588206-Vimentin,
pubmed-meshheading:20588206-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Intragraft tubular vimentin and CD44 expression correlate with long-term renal allograft function and interstitial fibrosis and tubular atrophy.
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pubmed:affiliation |
Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. j.kers@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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