Source:http://linkedlifedata.com/resource/pubmed/id/20587604
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
18
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| pubmed:dateCreated |
2010-8-26
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| pubmed:abstractText |
Several genome-wide association studies identified the chr15q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell proliferation gene (PSMA4), for its association with lung cancer risk in Caucasians. A haplotype and its tagging single nucleotide polymorphisms (SNPs) encompassing six genes from IREB2 to CHRNB4 were most strongly associated with lung cancer risk (OR = 1.3; P < 10(-20)). In order to narrow the region of association and identify potential causal variations, we performed a fine-mapping study using 77 SNPs in a 194 kb segment of the 15q25.1 region in a sample of 448 African-American lung cancer cases and 611 controls. Four regions, two SNPs and two distinct haplotypes from sliding window analyses, were associated with lung cancer. CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk. Lung cancer associations remained significant after pack-year adjustment. Rs7178270 decreased lung cancer risk in women but not in men; gender interaction P = 0.009. For two SNPs (rs7168796 A/G and rs7164594 A/G) upstream of PSMA4, lung cancer risks for people with haplotypes GG and AA were reduced compared with those with AG (OR = 0.56, 95% CI 0.38-0.82; P = 0.003 and OR = 0.73, 95% CI 0.59-0.90, P = 0.004, respectively). A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CHRNA5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/nicotinic receptor subunit alpha3
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1460-2083
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| pubmed:author |
pubmed-author:BracciPaige MPM,
pubmed-author:ChangJeffery SJS,
pubmed-author:HansenHelen MHM,
pubmed-author:KelseyKarl TKT,
pubmed-author:PatokaJosephJ,
pubmed-author:QuesenberryCharles PCP,
pubmed-author:RiceTerriT,
pubmed-author:SeldinMichael FMF,
pubmed-author:SisonJennette DJD,
pubmed-author:SmirnovIvan VIV,
pubmed-author:WienckeJohn KJK,
pubmed-author:WrenschMargaret RMR,
pubmed-author:XiaoYuanyuanY
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| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3652-61
|
| pubmed:dateRevised |
2011-9-16
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| pubmed:meshHeading |
pubmed-meshheading:20587604-Adolescent,
pubmed-meshheading:20587604-Adult,
pubmed-meshheading:20587604-African Americans,
pubmed-meshheading:20587604-Aged,
pubmed-meshheading:20587604-Case-Control Studies,
pubmed-meshheading:20587604-Chromosome Mapping,
pubmed-meshheading:20587604-Chromosomes, Human, Pair 15,
pubmed-meshheading:20587604-Female,
pubmed-meshheading:20587604-Genetic Predisposition to Disease,
pubmed-meshheading:20587604-Haplotypes,
pubmed-meshheading:20587604-Humans,
pubmed-meshheading:20587604-Lung Neoplasms,
pubmed-meshheading:20587604-Male,
pubmed-meshheading:20587604-Middle Aged,
pubmed-meshheading:20587604-Nerve Tissue Proteins,
pubmed-meshheading:20587604-Polymorphism, Single Nucleotide,
pubmed-meshheading:20587604-Receptors, Nicotinic,
pubmed-meshheading:20587604-Smoking,
pubmed-meshheading:20587604-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans.
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| pubmed:affiliation |
Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|