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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-28
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pubmed:abstractText |
?Anagrelide is a selective inhibitor of megakaryocytopoiesis used to treat thrombocytosis in patients with chronic myeloproliferative disorders. The effectiveness of anagrelide in lowering platelet counts is firmly established, but its primary mechanism of action remains elusive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombopoietin,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ZFPM1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/anagrelide
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 International Society on Thrombosis and Haemostasis.
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2252-61
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pubmed:meshHeading |
pubmed-meshheading:20586925-Antigens, CD34,
pubmed-meshheading:20586925-Blood Platelets,
pubmed-meshheading:20586925-Cell Line,
pubmed-meshheading:20586925-GATA1 Transcription Factor,
pubmed-meshheading:20586925-Gene Expression Regulation,
pubmed-meshheading:20586925-Humans,
pubmed-meshheading:20586925-Megakaryocytes,
pubmed-meshheading:20586925-Nuclear Proteins,
pubmed-meshheading:20586925-Phosphorylation,
pubmed-meshheading:20586925-Platelet Aggregation,
pubmed-meshheading:20586925-Platelet Aggregation Inhibitors,
pubmed-meshheading:20586925-Quinazolines,
pubmed-meshheading:20586925-Receptors, Thrombopoietin,
pubmed-meshheading:20586925-Signal Transduction,
pubmed-meshheading:20586925-Transcription, Genetic,
pubmed-meshheading:20586925-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction.
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pubmed:affiliation |
University of Wales Institute, Cardiff School of Health Sciences, Cardiff, UK.
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pubmed:publicationType |
Journal Article
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