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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2010-7-29
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pubmed:abstractText |
Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory peptides caused a remarkable inhibition of the strand transfer and 3'-end-processing reactions catalyzed by IN and significant inhibition against HIV replication.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HIV Integrase,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Integrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Human Immunodeficiency Virus...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Library,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/env Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/p31 integrase protein, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/vpr Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BeutlerJohn AJA,
pubmed-author:FujiHideyoshiH,
pubmed-author:HamatakeMakikoM,
pubmed-author:HanYanY,
pubmed-author:HashimotoChieC,
pubmed-author:HoshinoTyujiT,
pubmed-author:ItotaniKyokoK,
pubmed-author:KomanoJun AJA,
pubmed-author:MaddaliKasthuraiahK,
pubmed-author:MiyauchiKosukeK,
pubmed-author:NakaharaToruT,
pubmed-author:NakanishiYutaY,
pubmed-author:NarumiTetsuoT,
pubmed-author:NomuraWataruW,
pubmed-author:PommierYvesY,
pubmed-author:SugiuraWataruW,
pubmed-author:SuzukiShintaroS,
pubmed-author:TamamuraHirokazuH,
pubmed-author:TanakaTomohiroT,
pubmed-author:TsutsumiHiroshiH,
pubmed-author:UranoEmikoE,
pubmed-author:YamamotoNaokiN
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5356-60
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pubmed:meshHeading |
pubmed-meshheading:20586421-Amino Acid Sequence,
pubmed-meshheading:20586421-Cell Line,
pubmed-meshheading:20586421-Cell Line, Tumor,
pubmed-meshheading:20586421-Genes, Viral,
pubmed-meshheading:20586421-HIV Integrase,
pubmed-meshheading:20586421-HIV Integrase Inhibitors,
pubmed-meshheading:20586421-HIV-1,
pubmed-meshheading:20586421-Human Immunodeficiency Virus Proteins,
pubmed-meshheading:20586421-Humans,
pubmed-meshheading:20586421-Models, Molecular,
pubmed-meshheading:20586421-Peptide Library,
pubmed-meshheading:20586421-Peptides,
pubmed-meshheading:20586421-Virus Replication,
pubmed-meshheading:20586421-env Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:20586421-vpr Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2010
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pubmed:articleTitle |
Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
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pubmed:affiliation |
Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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