Linked Life Data

20585893

Source:http://linkedlifedata.com/resource/pubmed/id/20585893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-8-30
pubmed:abstractText
Protein phosphatase 2A (PP-2A) has been implicated to be crucial in neural development and the normal function of nervous system. However, little is known about its role in neuritogenesis. In this study, we reported that inhibition of PP-2A strongly suppresses the outgrowth of cell processes only during the initiation stage, while activation of PP-2A promotes extensive outgrowth of long neurites in Neura2A cells and long single axon or multiple axons in hippocampal neurons. Our results indicated that PP-2A may be an important positive regulator in neurite outgrowth, and upregulation PP-2A could be a possible target for the therapy of axonopathy in neural diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1543-706X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
702-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effect of PP-2A on neurite outgrowth in neuronal cells.
pubmed:affiliation
Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't