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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
Relatively few studies have been performed on molecular properties of pediatric glioblastoma multiforme (GBM). Methylation of DNA repair gene O(6)-methylguanine-DNA methyltransferase (MGMT) promoter region has been associated with favorable prognosis and prolonged survival in adult GBM patients treated with temozolomide (TMZ). We explored the frequency of MGMT gene promoter methylation in pediatric glioblastomas and compared it with the known molecular alterations in p53.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1433-0350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1613-8
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pubmed:meshHeading |
pubmed-meshheading:20585787-Adolescent,
pubmed-meshheading:20585787-Antineoplastic Agents, Alkylating,
pubmed-meshheading:20585787-Brain Neoplasms,
pubmed-meshheading:20585787-Child,
pubmed-meshheading:20585787-Child, Preschool,
pubmed-meshheading:20585787-DNA Methylation,
pubmed-meshheading:20585787-DNA Modification Methylases,
pubmed-meshheading:20585787-DNA Repair Enzymes,
pubmed-meshheading:20585787-Dacarbazine,
pubmed-meshheading:20585787-Female,
pubmed-meshheading:20585787-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20585787-Glioblastoma,
pubmed-meshheading:20585787-Humans,
pubmed-meshheading:20585787-Immunoenzyme Techniques,
pubmed-meshheading:20585787-Infant,
pubmed-meshheading:20585787-Male,
pubmed-meshheading:20585787-Polymerase Chain Reaction,
pubmed-meshheading:20585787-Prognosis,
pubmed-meshheading:20585787-Promoter Regions, Genetic,
pubmed-meshheading:20585787-Tumor Suppressor Protein p53,
pubmed-meshheading:20585787-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
MGMT gene promoter methylation in pediatric glioblastomas.
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pubmed:affiliation |
Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
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pubmed:publicationType |
Journal Article
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