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rdf:type |
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lifeskim:mentions |
umls-concept:C0021368,
umls-concept:C0027051,
umls-concept:C0033414,
umls-concept:C0035955,
umls-concept:C0040661,
umls-concept:C0205365,
umls-concept:C0549178,
umls-concept:C1274040,
umls-concept:C1522565,
umls-concept:C1705162,
umls-concept:C1710082,
umls-concept:C1879547
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pubmed:issue |
2
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pubmed:dateCreated |
2010-7-13
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pubmed:abstractText |
In patients with myocardial infarction, high serum levels of interleukin-6 cytokines predict a poor outcome. The common receptor of interleukin-6 cytokines, glycoprotein-130 (gp130), signals via janus kinase/signal transducer and activator of transcription (STAT), cytoplasmic protein tyrosine phosphatase/extracellular signal-regulated kinase, and phosphoinositide-3-kinase/Akt pathways, and the regulation of these pathways depends at least in part on the gp130 tyrosine-757 residue. By analyzing cardiomyocyte-specific gp130(Y757F) mutant mice, we investigated the effect of disturbed gp130 signaling after myocardial infarction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokine Receptor gp130,
http://linkedlifedata.com/resource/pubmed/chemical/IL6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IL6ST protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il6st protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:DrexlerHelmutH,
pubmed-author:ErnstMatthiasM,
pubmed-author:Hilfiker-KleinerDeniseD,
pubmed-author:HilfikerAndresA,
pubmed-author:HochMelanieM,
pubmed-author:KleinGunnarG,
pubmed-author:MüllerWernerW,
pubmed-author:SchaeferArndA,
pubmed-author:ScherrMichaelaM,
pubmed-author:ShuklaPraphullaP,
pubmed-author:StapelBrittaB,
pubmed-author:TheilmeierGregorG
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-55
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pubmed:meshHeading |
pubmed-meshheading:20585009-Animals,
pubmed-meshheading:20585009-Cytokine Receptor gp130,
pubmed-meshheading:20585009-Down-Regulation,
pubmed-meshheading:20585009-Humans,
pubmed-meshheading:20585009-Interleukin-6,
pubmed-meshheading:20585009-Mice,
pubmed-meshheading:20585009-Mice, Mutant Strains,
pubmed-meshheading:20585009-Mutation, Missense,
pubmed-meshheading:20585009-Myocardial Infarction,
pubmed-meshheading:20585009-Myocarditis,
pubmed-meshheading:20585009-Myocytes, Cardiac,
pubmed-meshheading:20585009-Rupture, Spontaneous,
pubmed-meshheading:20585009-STAT3 Transcription Factor
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pubmed:year |
2010
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pubmed:articleTitle |
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
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pubmed:affiliation |
Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany. Hilfiker.denise@mh-hannover.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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