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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-7-1
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pubmed:abstractText |
Focal somatic pain can evolve into widespread hypersensitivity to nonpainful and painful skin stimuli (allodynia and hyperalgesia, respectively). We hypothesized that transformation of headache into whole-body allodynia/hyperalgesia during a migraine attack is mediated by sensitization of thalamic neurons that process converging sensory impulses from the cranial meninges and extracephalic skin.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-10204729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-10332889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-10908199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-11166465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-11293599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-11323148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-11707093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-11738036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-1309578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-14065328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-14648689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-15501092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-15574468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-15638182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-15845999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-16842915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-17050704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-1705972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-1723993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-17407825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-17640049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-19259966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-3351579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-3409027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-3742223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-4132971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-5075704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-530514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-7430431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-7553808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-7585147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-762271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-7751959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-7965079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-8955268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-9212262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20582997-9463456
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1531-8249
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-91
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:20582997-Action Potentials,
pubmed-meshheading:20582997-Adolescent,
pubmed-meshheading:20582997-Adult,
pubmed-meshheading:20582997-Animals,
pubmed-meshheading:20582997-Cerebrovascular Circulation,
pubmed-meshheading:20582997-Dura Mater,
pubmed-meshheading:20582997-Hot Temperature,
pubmed-meshheading:20582997-Humans,
pubmed-meshheading:20582997-Magnetic Resonance Imaging,
pubmed-meshheading:20582997-Male,
pubmed-meshheading:20582997-Microelectrodes,
pubmed-meshheading:20582997-Middle Aged,
pubmed-meshheading:20582997-Migraine Disorders,
pubmed-meshheading:20582997-Oxygen,
pubmed-meshheading:20582997-Pain,
pubmed-meshheading:20582997-Physical Stimulation,
pubmed-meshheading:20582997-Rats,
pubmed-meshheading:20582997-Rats, Sprague-Dawley,
pubmed-meshheading:20582997-Sensory Receptor Cells,
pubmed-meshheading:20582997-Thalamus,
pubmed-meshheading:20582997-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Thalamic sensitization transforms localized pain into widespread allodynia.
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pubmed:affiliation |
Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA. rburstei@bidmc.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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