Linked Life Data

2058222

Source:http://linkedlifedata.com/resource/pubmed/id/2058222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-1
pubmed:abstractText
Little is known about the absorption of theophylline from definite parts of the intestine, though there are many depot or slow-release formulations of theophylline on the market and this topic should be of relevant importance. Most of these formulations are releasing the drug for up to 24 hours while passing the bowels. In this prospective, open, randomised, study with an interchange trial design the absorption of theophylline from the colon was studied in eight healthy male volunteers: 400 mg theophylline was given intravenously and in two different forms into the colon transversum by application with an endoscope. Under these conditions, theophylline was absorbed in an amount of 54% on the average with some variation due to the applied formulation. Therefore, it could be concluded that theophylline is absorbed to a clinically relevant extent from the large intestine. These results are remarkable with regard to the development and pharmaceutical profiles of retard or slow-release formulations of theophylline and the undesired effects of this therapy.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0044-2771
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Gastrointestinal absorption of theophylline, especially with reference to retard preparations].
pubmed:affiliation
Abteilung für Klinische Pharmakologie, 1. Medizinische Universitätsklinik, Wien.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial