|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-7-2
|
|
pubmed:abstractText |
The ubiquitin ligase APC/C(Cdh1) coordinates degradation of key cell cycle regulators. We report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded by the APC/C(Cdh1) during exit from mitosis and the G1 phase of the cell cycle. Expression of a non-degradable JNK induces prometaphase-like arrest and aberrant mitotic spindle dynamics. Moreover, JNK phosphorylates Cdh1 directly, during G2 and early mitosis, changing its subcellular localization and attenuating its ability to activate the APC/C during G2/M. This regulatory mechanism between JNK and Cdh1 reveals an important function for JNK during the cell cycle.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10074450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10548110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10694434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10733526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10793135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-10921876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-11340163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-11562349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-11598127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-11910072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-11988738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-12070128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-12198152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-15029244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-15467459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16122424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16236519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16337124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16647857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16878123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16896351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16921029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16964245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-16973441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-18256527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-18431843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-18662541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-20220133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-8943238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-9831566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20581839-9885559
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1476-4679
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
686-95
|
|
pubmed:dateRevised |
2011-7-19
|
|
pubmed:meshHeading |
pubmed-meshheading:20581839-Cadherins,
pubmed-meshheading:20581839-Cell Cycle,
pubmed-meshheading:20581839-Cell Line,
pubmed-meshheading:20581839-Flow Cytometry,
pubmed-meshheading:20581839-G1 Phase,
pubmed-meshheading:20581839-HeLa Cells,
pubmed-meshheading:20581839-Humans,
pubmed-meshheading:20581839-Immunoprecipitation,
pubmed-meshheading:20581839-MAP Kinase Kinase 4,
pubmed-meshheading:20581839-Mitosis,
pubmed-meshheading:20581839-Phosphorylation
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Interplay between Cdh1 and JNK activity during the cell cycle.
|
|
pubmed:affiliation |
Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
