Source:http://linkedlifedata.com/resource/pubmed/id/20581744
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-9-16
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| pubmed:abstractText |
Oxidation of L[1-C]methionine ([C]-Met) in liver mitochondria can be quantified by measuring exhaled CO2. We hypothesized that CO2 recovery after i.v. administered [C]-Met would provide a noninvasive measure of liver function in pediatric intestinal failure-associated liver disease (IFALD). After Institutional Review Board (IRB) approval, 27 patients underwent L[1-C]-Met breath tests ([C]-MBTs), five of whom underwent repeat testing after clinical changes in liver function. Sterile, pyrogen-free [C]-Met was given i.v. Six breath samples collected during 120 min were analyzed for CO2 enrichment using isotope ratio mass spectrometry. Pediatric end-stage liver disease (PELD) scores were recorded, and total carbon dioxide (CO2) production was measured by indirect calorimetry. Twenty-seven patients (median age = 5.3 mo) underwent a total of 34 [C]-MBTs without adverse events. Fourteen patients had documented liver biopsies (five with cirrhosis and nine with cholestasis or fibrosis). The [C]-MBT differentiated patients with and without cirrhosis (medians 210 and 350, respectively, p = 0.04). Serial [C]-MBTs in five patients reflected changing PELD scores. i.v. administering the stable isotope [C]-Met with serial breath sampling provides a useful, safe, and potentially clinically relevant evaluation of hepatic function in pediatric IFALD. The [C]-MBT may also help quantify progression or improvement of IFALD.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
1530-0447
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| pubmed:author |
pubmed-author:BechardLoriL,
pubmed-author:DolanMelanieM,
pubmed-author:DugganChristopherC,
pubmed-author:DuroDeboraD,
pubmed-author:FitzgibbonsShimaeS,
pubmed-author:JaksicTomT,
pubmed-author:ValimClarissaC,
pubmed-author:YangChi-Fu JeffreyCF,
pubmed-author:YuYong MingYM,
pubmed-author:ZurakowskiDavidD
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
349-54
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| pubmed:dateRevised |
2011-10-5
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| pubmed:meshHeading |
pubmed-meshheading:20581744-Biopsy,
pubmed-meshheading:20581744-Boston,
pubmed-meshheading:20581744-Breath Tests,
pubmed-meshheading:20581744-Calorimetry, Indirect,
pubmed-meshheading:20581744-Carbon Dioxide,
pubmed-meshheading:20581744-Carbon Isotopes,
pubmed-meshheading:20581744-Feasibility Studies,
pubmed-meshheading:20581744-Female,
pubmed-meshheading:20581744-Humans,
pubmed-meshheading:20581744-Infant,
pubmed-meshheading:20581744-Injections, Intravenous,
pubmed-meshheading:20581744-Intestinal Diseases,
pubmed-meshheading:20581744-Liver,
pubmed-meshheading:20581744-Liver Diseases,
pubmed-meshheading:20581744-Liver Function Tests,
pubmed-meshheading:20581744-Male,
pubmed-meshheading:20581744-Mass Spectrometry,
pubmed-meshheading:20581744-Methionine,
pubmed-meshheading:20581744-Mitochondria, Liver,
pubmed-meshheading:20581744-Predictive Value of Tests,
pubmed-meshheading:20581744-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
[13C]Methionine breath test to assess intestinal failure-associated liver disease.
|
| pubmed:affiliation |
Division of Gastroenterology and Nutrition, Children Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|