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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-10-15
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pubmed:abstractText |
An activated vasoconstrictive, proliferative, and fibrotic axis of the renin angiotensin system (angiotensin-converting enzyme [ACE]/angiotensin [Ang]II/AngII type 1 receptor) has been implicated in the pathophysiology of pulmonary fibrosis (PF) and pulmonary hypertension (PH). The recent discovery of a counterregulatory axis of the renin angiotensin system composed of ACE2/Ang-(1-7)/Mas has led us to examine the role of this vasoprotective axis on such disorders.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1535-4970
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pubmed:author |
pubmed-author:Díez-FreireCarlosC,
pubmed-author:DooiesAutumnA,
pubmed-author:FerreiraAnderson JAJ,
pubmed-author:Fraga-SilvaRodrigo ARA,
pubmed-author:FrancisJosephJ,
pubmed-author:JunJoo YunJY,
pubmed-author:KatovichMichael JMJ,
pubmed-author:NithyaMariappanM,
pubmed-author:PatelJawaharlal MJM,
pubmed-author:PourangDornaD,
pubmed-author:QiYanfeiY,
pubmed-author:RaizadaMohan KMK,
pubmed-author:ReudelhuberTimothyT,
pubmed-author:SantosRobson ARA,
pubmed-author:ShenoyVinayakV,
pubmed-author:SrinivasSriramulaS,
pubmed-author:VenugopalChangaram SCS
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-72
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pubmed:dateRevised |
2011-10-17
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pubmed:meshHeading |
pubmed-meshheading:20581171-Angiotensin I,
pubmed-meshheading:20581171-Animals,
pubmed-meshheading:20581171-Bleomycin,
pubmed-meshheading:20581171-Gene Therapy,
pubmed-meshheading:20581171-Hypertension, Pulmonary,
pubmed-meshheading:20581171-Male,
pubmed-meshheading:20581171-Peptide Fragments,
pubmed-meshheading:20581171-Peptidyl-Dipeptidase A,
pubmed-meshheading:20581171-Proto-Oncogene Proteins,
pubmed-meshheading:20581171-Pulmonary Fibrosis,
pubmed-meshheading:20581171-Rats,
pubmed-meshheading:20581171-Rats, Sprague-Dawley,
pubmed-meshheading:20581171-Receptors, G-Protein-Coupled,
pubmed-meshheading:20581171-Renin-Angiotensin System,
pubmed-meshheading:20581171-Transduction, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.
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pubmed:affiliation |
Department of Pharmacodynamics, University of Florida, Gainesville, Florida, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies,
Research Support, N.I.H., Extramural
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