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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-26
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pubmed:abstractText |
Availability of peripheral biomarkers for depression could aid diagnosis and help to predict treatment response. The objective of this work was to analyse the peripheral biomarker response in a gene-environment interaction model of depression. Genetically selected Flinders Sensitive Line (FSL) rats were subjected to maternal separation (MS), since early-life trauma is an important antecedent of depression. An open-ended approach based on a proteomic analysis of serum was combined with the evaluation of depression-associated proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1878-4216
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1037-48
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pubmed:meshHeading |
pubmed-meshheading:20580919-Animals,
pubmed-meshheading:20580919-Biological Markers,
pubmed-meshheading:20580919-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:20580919-C-Reactive Protein,
pubmed-meshheading:20580919-Citalopram,
pubmed-meshheading:20580919-Corticosterone,
pubmed-meshheading:20580919-Cytokines,
pubmed-meshheading:20580919-Depressive Disorder,
pubmed-meshheading:20580919-Disease Models, Animal,
pubmed-meshheading:20580919-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:20580919-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20580919-Immunoassay,
pubmed-meshheading:20580919-Maternal Deprivation,
pubmed-meshheading:20580919-Nortriptyline,
pubmed-meshheading:20580919-Proteomics,
pubmed-meshheading:20580919-Rats,
pubmed-meshheading:20580919-Stress, Psychological
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pubmed:year |
2010
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pubmed:articleTitle |
Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression.
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pubmed:affiliation |
Neurosciences CEDD, GlaxoSmithKline, Verona, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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