Source:http://linkedlifedata.com/resource/pubmed/id/20580898
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-7-15
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| pubmed:abstractText |
The objective of this prospective cohort study was to elucidate whether bacterial vaginosis (BV) is associated with a pro-inflammatory endometrial secretion cytokine profile and whether there is a relationship between BV and the concentrations of a number of key regulatory cytokines, chemokines and growth factors. A total of 198 women undergoing IVF treatment were included. Prior to embryo transfer, participants underwent screening for BV according to Nugent criteria by a Gram-stained cervical smear. The concentrations of 17 soluble mediators of human implantation were measured by multiplex immunoassay in endometrial secretions aspirated prior to embryo transfer. Seventeen (8.6%) women had BV (Nugent score >6). Multivariable logistic regression showed a significant positive association between interleukin-beta and the presence of BV (P=0.011; Nugent score >6 versus 6) and a significant negative association between eotaxin and BV (P=0.003). No significant differences were found in the ratios of distinct pro- and anti-inflammatory cytokines in endometrial secretions from women with or without BV. In conclusion, BV is associated with higher concentrations of interleukin-beta in endometrial secretions compared with women without BV. However, no distinct difference in pro- and anti-inflammatory profiles is present. An effect on endometrial receptivity is unlikely.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1472-6491
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| pubmed:author | |
| pubmed:copyrightInfo |
2010. Published by Elsevier Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
133-41
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| pubmed:meshHeading |
pubmed-meshheading:20580898-Adult,
pubmed-meshheading:20580898-Chemokines,
pubmed-meshheading:20580898-Cohort Studies,
pubmed-meshheading:20580898-Cytokines,
pubmed-meshheading:20580898-Endometrium,
pubmed-meshheading:20580898-Female,
pubmed-meshheading:20580898-Fertilization in Vitro,
pubmed-meshheading:20580898-Humans,
pubmed-meshheading:20580898-Inflammation,
pubmed-meshheading:20580898-Prospective Studies,
pubmed-meshheading:20580898-Vaginal Smears,
pubmed-meshheading:20580898-Vaginosis, Bacterial
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| pubmed:year |
2010
|
| pubmed:articleTitle |
Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF?
|
| pubmed:affiliation |
Department of Reproductive Medicine and Gynecology, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. c.m.boomsma@umcutrecht.nl
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| pubmed:publicationType |
Journal Article
|